Mechanical sensitivity of carotid body glomus cells
نویسندگان
چکیده
منابع مشابه
Mechanisms of low-glucose sensitivity in carotid body glomus cells.
OBJECTIVE Glucose sensing is essential for the adaptive counterregulatory responses to hypoglycemia. We investigated the mechanisms underlying carotid body (CB) glomus cells activation by low glucose. RESEARCH DESIGN/METHODS AND RESULTS Removal of extracellular glucose elicited a cell secretory response, abolished by blockade of plasma membrane Ca(2+) channels, and a reversible increase in cy...
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Address reprint requests to Dr. A. Roos, Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110. J. GEN. Pm'SlOL. © The Rockefeller University Press • 0022-1295/92/1010593/16 $2.00 Volume 100 October 1992 593-608 593 on Jne 5, 2017 D ow nladed fom Published October 1, 1992
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متن کاملAcid-sensing ion channels contribute to transduction of extracellular acidosis in rat carotid body glomus cells.
Carotid body chemoreceptors sense hypoxemia, hypercapnia, and acidosis and play an important role in cardiorespiratory regulation. The molecular mechanism of pH sensing by chemoreceptors is not clear, although it has been proposed to be mediated by a drop in intracellular pH of carotid body glomus cells, which inhibits a K+ current. Recently, pH-sensitive ion channels have been described in glo...
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ژورنال
عنوان ژورنال: Respiratory Physiology & Neurobiology
سال: 2008
ISSN: 1569-9048
DOI: 10.1016/j.resp.2008.01.007